Chemical Composition of the Essential Oil of Catha edulis Forsk from Djibouti and Its Toxicological Investigations In Vivo and In Vitro

This work aimed to evaluate the chemical composition of essential oils from Catha edulis Forsk collected in Day Forest Republic Djibouti. Additionally, vivo toxicity studies, biochemical profiling, and hematological tests were conducted determine biological activity investigated oils. Finally, vitro performed investigate antibacterial The obtained at yields 0.75%. Chromatographic analysis identified 39 compounds, which cathinone (81.4%) cathine (10.55%) determined as two major components, representing 91.95% total composition. oil had a rat LD50 2500 mg/kg, indicating very low toxicity. Chronic exposure studies revealed that use rats resulted persistent stimulant action dosages 100 200 whereas weight gain control was faster than oil-treated rats. Hematological parameters showed significant increase red blood cell counts, hemoglobin, hematocrit, platelets treated rats, could indicate hyperviscosity may risk clots cardiovascular diseases. Furthermore, exhibited antimicrobial against several bacterial strains.